Advanced information on some of the features and challenges for a child with Down Syndrome
The child with Down Syndrome
In the child with Down Syndrome, it is imperative that the parents become educated to understand what is happening inside their child’s body and cells. It does help to have a basic knowledge of cell biology, and also a basic knowledge of biochemistry, before attempting to master this important subject. It is the parent’s responsibility to become educated in their child’s condition to stay abreast of the dynamic needs of the child with Down Syndrome.
Down Syndrome behaves much like a degenerative disease. In the child with Down Syndrome there is much biochemical damage done to the cells because of the replicated 21st chromosome that is a part of the child’s genetic make-up. In order to gain an overview of this subject we will first discuss basic biology and cellular structure as it relates to Down Syndrome. This will be followed up by cellular function as it relates to Down Syndrome with a particular focus on nerve cells and neurotransmitters.
Understanding the Cell Membrane in Down Syndrome
The normal healthy cell consists of an outer cell membrane, the liquid cytoplasm interior, the nucleus which contains the DNA, and various organelles to perform different tasks within the cell. The cell membrane is composed of phospholipids which repel water on one side and attract water on the other side. The outer end of the phospholipids membrane is hydrophyllic or “water loving”. This is the phosphate end of the phospholipid. The other end is hydrophobic or “water hating”. This inside end of the phospholipid membrane is comprised of fatty acid chains.
Phospholipids spontaneously line up to form the cell membrane in bilipid layers by putting their heads outward and butt tail to tail with another phospholipid to form a unique selectively-permeable membrane. This membrane has the ability to keep fat and water-based chemicals out of the cell while still allowing water, oxygen, and carbon dioxide to pass through. It also allows enough flexibility to incorporate different transport proteins among them. A model of cell membranes:
Some transport proteins move nutrients and chemicals into the cell while other transport proteins move waste material out of the cell. This is critical for healthy function of the cell. For the transport to work correctly, the cell membrane must remain fluid for the protein to change shape as it transports different shape and sized nutrients, chemicals, and wastes in or out of the cell. If the proteins are limited in their flexibility by limited flexibility of the cell wall they cannot properly perform their functions. Fluid movement of the cell walls is lost in the natural aging process of the body. Loss of fluid movement in the cell wall is accelerated in the child with Down Syndrome and is a particular problem for Down Syndrome.
In the child with Down Syndrome, the fatty acid portions of the cell membrane is more prone to chemical damage than the genetically “normal” subject. This damage is a process called lipoperoxidation, or “oxidative stress.” The end result of this oxidative stress is that the cell membrane loses its flexibility and the transport proteins can no longer function properly. When transport proteins do not function properly, chemical waste begins to accumulate inside the cell and ultimately kill the cell. The cell also begins to starve for nutrients because it can no longer effectively transport its food from the outside world in.
Supplementing with mixed tocopherol Vitamin E is essential for the child with Down Syndrome to help protect against oxidative stress. Supplementing with essential fatty acids provides the needed materials to repair damaged cell membranes.
The Cell Nucleus in Down Syndrome
The cell nucleus is where the DNA (Deoxyribonucleic Acid) resides in a cell. This is where the process of “protein synthesis” occurs. To make a protein, a portion of the DNA inside of the nucleus unzips to form a section of RNA (a molecule similar to DNA, which is used in the making of proteins). A new strand of RNA is formed to match the unzipped DNA portion. Amino acids are the building blocks of proteins that are then strung together according to the instructions in the RNA to make the protein. Once the protein is made, it moves to the place in the cell where it is needed to perform a specific job.
DNA production in the child with Down Syndrome is one of the places where the extra 21st chromosome comes into play. Chromosomes are made of DNA, but because there is an extra copy of the 21st chromosome in each cell of the child with Down Syndrome. This means there are more copies of proteins produced than are needed for the normal chemical reactions that occur in a cell. In some cases, these extra proteins cause metabolic imbalances, which lead to an excess (an over-expression) of some metabolic chemicals and a deficiency (under-expression) of others in the child with Down Syndrome’s body. (Keep in mind that metabolism is the sum total of all the chemical reactions in the body.)
An example of excess that causes metabolic imbalance is the superoxide dismutase or SOD gene which is on the 21st chromosome. SOD is half of a two-step process to take a poisonous form of oxygen, called superoxide, and turn it into oxygen and water. This SOD, because it is manufactured on the replicated 21st chromosome, is made in larger quantity than normal. The enzymes used in the other half of this process is either catalase or glutathione peroxidase Glutathione peroxidase and catalase is not replicated as is SOD and is therefore not over-expressed.
In the first step of this two-step process, SOD takes the toxic superoxide and turns it into hydrogen peroxide. However, in step two of this in the child with Down Syndrome, there is not enough glutathione peroxidase and catalase to break down the hydrogen peroxide into oxygen and water fast enough. This leaves excess hydrogen peroxide in the cells until it finally reaches toxic levels and eventually destroys the cell from within. This is called Oxidation–the same process that rusts metals and turns apples brown. Hydrogen Peroxide is especially toxic to nerve cells. Hydrogen peroxide also reacts when exposed to other chemicals and elements in the body such as iron that can cause even more cellular damage.
To address this problem what is required is a variety of supplemental antioxidants, vitamins and minerals that keep the oxidative damage from occurring, and in some cases, even repair the cellular damage and loss of fluidity that has occurred in the child with Down Syndrome .
Some key antioxidants include Vitamins A (beta-carotene), C, and mixed tocopherol E, the minerals zinc and selenium, Alpha Lipoic Acid, Co-Q10, inositol and bioflavinoids.
Structure of a nerve cell in Down Syndrome
Myelination of the brain and central nervous system has a direct correlation to brain development and lack of myelination or slow myelination correlates directly to developmental delays. Beginning at about two months of age, myelin formation in the child with Down Syndrome slows in the brain as compared to genetically normal children.
The glial cells which make up the myelin sheath consist mainly of the cell membrane and very little cytoplasm. The cell membranes of glial cells are made up of a lipid-protein mixture that is slightly different than other types of cells. This makes the myelin to consist of a higher proportion of lipids or fats than any other type of cell. A majority of these fats are docosahexaenoic acid, or DHA. DHA is an essential fatty acid and part of the omega 3,6,9 supplements.
One significant difference between nerve cells (neurons) and other body cells is that mature neurons do not typically reproduce. If a neuron dies, if for example by oxidative damage (more-so in the child with Down Syndrome), then that cell is normally lost forever.
To elaborate on myelination which will be a challenge for the child with Down Syndrome: The brain and spinal cord are comprised mainly of nerve cells. There are significant differences between a nerve cell and other cells in the body. Nerve cells have a number of “tentacles” which stick out from the cell body called dendrites. Dendrites receive messages from other nerve cells. Then there is the axon of the nerve cell that protrudes farther away from the cell body than the dendrites. The axon transmits the neurochemical message that is picked up by the next cell’s dendrites.
Nerve impulses always flows through the cell body, and down the axon to the next cell’s dendrites. The next cell repeats the process until the message reaches it’s destination at the end of the neuropathway. At the end of the neuropathway, the nerve cell will connect to a muscle or an organ in the body system.
The process of learning causes new connections to be made from one neuron to another. As the connections are repeated over and over, the cells form a deeper, wider neuropathway much like a cow-trail in a pasture. The more cows that repeatedly use the trail the deeper and wider the trail becomes. When connections are unused for a period of time, they begin to die off and are pruned by the body much like the cow-trail will fade and overgrow when the cows quit using it.
These neuropathways are ultimately covered with an insulating coating called myelin. Myelin is a fatty sheath that is formed by another type of cell called a glial cell. The whole human brain takes years to myelinate starting in the lower parts of the brain and insulating upwards to finally myelinate the cerebral cortices. This process starts soon after conception and continues on until about 20-23 years of age. The myelin sheath forms by wrapping itself tightly around the axon like wrapping electrical tape around a live electrical wire. Myelin assists the neuron to send neurochemical messages more quickly and keeps the signals from bleeding over into other impulses from proximal neurons.
This is why it is imperative that the child with Down Syndrome receives lots of supplemental essential fatty acids like supplied in a quality fish oil.
Function of Neurotransmitters in Down Syndrome
When the typical neuron is stimulated, an electrical/chemical impulse is made which travels down the dendrites, through the cell body and then down the axon. At the end of the axon are bell-shaped synaptic knobs which connect to other neurons. The synaptic knobs contain the chemicals called neurotransmitters. The synapse is the gap between the two nerve cells where the exchange of neurotransmitter chemicals takes place. When the neuroimpulse reaches the synaptic knob, the synaptic knob releases a neurotransmitter into the synapse. The next neuron in line uses receptors to detect the neurotransmitter. If enough neurotransmitter chemical has been released for that nerve to fire then the neurochemical transmission continues through the next neuron and then on to the next and so on.
After the neurotransmitter has been released into the synaptic gap, the neurotransmitter is either reabsorbed into the synaptic knob or is destroyed by enzymes in the synapse. This process of removing the neurotransmitter from the synaptic gap prevents the recipient neuron from being continuously stimulated.
The end result of the synaptic firing of neurotransmitters is thought processes, muscle movement, organ and glandular function, and pain sensation to name a few.
There are often definite shortfalls in these neurotransmitters for the child with Down Syndrome:
Acetylcholine is the primary neurotransmitter in the central nervous system that activates muscle fibers, releases hormones, and is essential in the learning and memory processes of the brain. Choline and inositol are what the body uses to produce acetylcholine and can be supplemented to help overcome a shortfall in the body.
In the child with Down Syndrome there are fewer acetylcholine receptors in the brain causing some of the memory and learning problems found in Down Syndrome. This is because the nerves involved in these two processes are stimulated with less frequency and therefore have less opportunity to develop normally.
A lack of acetylcholine also accounts for faulty communications in the endocrine system resulting in glandular and hormonal shortfalls in the child with Down Syndrome. One such shortfall is in Human Growth Hormone (HGH) causing Down Syndrome features like short stature.
Serotonin is a neurotransmitter that controls blood pressure, sleep cycles, peristalsis (the movements of the intestines), and control of behavior (mood and aggression). Tryptophan is a primary amino acid which is converted into serotonin and requires vitamins B-6 and C for that conversion.
Serotonin is also used to produce melatonin which works in the sleep center of the brain to promote proper sleep. The brain releases the highest levels of Human Growth Hormone during the stage of sleep called Rapid Eye Movement (REM) sleep which helps to provide normal growth. Serotonin levels in the blood and cerebral spinal fluid are often deficient in the child with Down Syndrome.
Dopamine is the neurotransmitter that is involved what is called high order association which is the process in the brain that brings two separate pieces of information together for critical thinking. Dopamine also controls physical movements and coordinates processes in the brain. Tyrosine is a precursor to the production of dopamine. Dopamine is also converted to another neurotransmitter called epinephrine and then further converted to another neurotransmitter called norepinephrine. Dopamine levels are decreased in some children with Down Syndrome but not all.
Norepinephrine helps the brain to process sensory input from eyes and ears and tactile functions. It also regulates sleep cycles and influences anxiety and arousal.Tyrosine supplements help to increase the levels of norepinephrine which is found to be decreased in some children with Down Syndrome.
Read more in-depth with this book series: Fixing The Brain by Craig Stellpflug
Authored by Neurodevelopment Consultant Craig Stellpflug NDC, CNC, Healing Pathways Medical Clinic Scottsdale, AZ
Copyright 2009 Craig Stellpflug© Permission is hereby granted to copy and distribute this article but only in its entirety